ALIGNMENT INDEPENDENT 3D-QSAR, QUANTUM CALCULATIONS AND MOLECULAR DOCKING OF MER SPECIFIC TYROSINE KINASE INHIBITORS AS ANTICANCER DRUGS

Alignment independent 3D-QSAR, quantum calculations and molecular docking of Mer specific tyrosine kinase inhibitors as anticancer drugs

Mer receptor tyrosine kinase is revlon colorstay lip liner plum a promising novel cancer therapeutic target in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.3D-QSAR analyses based on alignment independent descriptors were performed on a series of 81 Mer specific tyrosine kinase

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Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms

Background: The protease-antiprotease hypothesis proposes that inflammatory cells and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which contribute to destruction of parenchyma resulting in progressive decline in forced expirat

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